Palmoplantar psoriasis can be challenging, but please don't lose hope?there are other effective options. Since methotrexate (Folitrax) hasn't helped, it is best to consult your dermatologist about alternative treatments. They may suggest switching to other oral medications like acitretin or cyclosporine, trying targeted phototherapy, or advancing to highly effective modern treatments called biologics. In the meantime, keeping your hands well-moisturized and using prescribed strong topical ointments can provide some relief.

Please do not abruptly stop your current medications, especially methotrexate (Folitrax), levothyroxine (throxin), folic acid, and paracetamol. Suddenly stopping these can cause severe joint flare-ups and thyroid complications. Any transition to complementary therapies must be done gradually and safely under the strict supervision of both your conventional specialists (rheumatologist and endocrinologist) and a qualified homeopathic doctor. For trusted homeopathic care in Mumbai, Thane, or Navi Mumbai, you may consider consulting established clinics like Dr. Batra's or visiting the outpatient departments of reputed homeopathic medical colleges.

Your normal ESR of 10 is very reassuring, showing that systemic inflammation is well-controlled. This stiffness doesn't necessarily mean your medications have stopped working; it could be caused by localized joint inflammation not fully reflected in blood tests, daily mechanical strain, or weather changes. I recommend discussing this with your rheumatologist, who can evaluate your joints and safely adjust your treatment plan or suggest supportive therapies to help you feel more comfortable.

While methotrexate (Folitrax) does carry risks of birth defects when taken close to conception, many healthy pregnancies occur in similar situations. First, please contact your obstetrician and rheumatologist immediately. They will likely recommend starting high-dose folic acid (usually 5mg daily) to help protect your baby and will schedule an early ultrasound to monitor your pregnancy closely.

Yes, her symptoms of severe stomach pain, vomiting, and white stools can point to a liver or bile duct issue, which can sometimes be linked to medications like Folitrax (methotrexate) or Wysolone (prednisolone). White stools suggest bile is not reaching her intestines properly. Please take her to the nearest hospital or consult her doctor immediately for a physical exam and liver function tests. It is best to hold her medication doses until a doctor evaluates her.

Since you are taking weekly Folitrax (methotrexate) and Medrol (methylprednisolone), it is possible you have a seronegative autoimmune condition, meaning joint inflammation is present even though your rheumatoid arthritis tests are negative. Ongoing symptoms suggest your current treatment might need adjustment, or there could be an underlying low-grade infection. I gently recommend discussing this with your rheumatologist. They can review your medications, check other inflammatory markers, and help find a plan to bring you much-deserved comfort and relief.