1. Consult Your Doctor First:
   Dosage adjustments should only be made under medical supervision to ensure your blood sugar remains controlled.

2. Monitor Blood Sugar Levels:
   Regular monitoring helps determine if a dosage change is safe and effective.

3. Understand Medication Roles:
   Glimepiride, Metformin, and Pioglitazone work together to manage diabetes; changing one affects overall control.

4. Watch for Symptoms:
   Be alert for signs of low blood sugar (hypoglycemia) or high blood sugar (hyperglycemia) if dosage is altered.

Always discuss any concerns or plans to change medication with your healthcare provider to ensure safe and effective diabetes management.