Since your fasting levels are high and you previously required insulin (Toujeo and Humalog) and metformin (Glycomet SR), your body likely needs a combination of these treatments again. It is very important to see your doctor or an endocrinologist immediately for a proper evaluation and a personalized prescription.

The excessive sweating and weakness she is experiencing while taking Glycomet-GP1 (which contains glimepiride and metformin) could be related to fluctuations in her blood sugar. While her fasting level of 93 is excellent, her after-meal level of 226 is high. Sometimes, active ingredients like glimepiride can cause blood sugar levels to drop quickly, triggering sweating and weakness. Please monitor her blood sugar levels right when she experiences these symptoms to catch any sudden drops. I assure you this is manageable; please consult her doctor to safely adjust her dosage and help stabilize her post-meal sugar levels.

Yes, you can take Januvia (sitagliptin) and Glycomet (metformin) together. Istamet is a combination pill containing both of these exact medicines, so taking them separately works the same way. However, please double-check your Glycomet dose with your doctor, as "1mg" is likely 1 gram (1000mg). It is safest to confirm that these individual doses match your prescribed Istamet strength before making the switch to ensure your blood sugar remains perfectly balanced.

It is completely understandable to feel frustrated by a weight loss plateau and uncomfortable constipation. Managing PCOD with Glycomet and recovering from H. pylori can temporarily disrupt your gut health. To help with constipation and kickstart your metabolism, focus on staying well-hydrated, gradually increasing dietary fiber, and incorporating gentle daily movement. Since H. pylori treatment can affect gut bacteria, a probiotic might also support your digestion. Please share your HbA1c and thyroid reports with your doctor, as optimizing your thyroid and insulin levels is key to overcoming weight plateaus in PCOD.

A prolactin level of 53.42 ng/mL is only mildly elevated, but it can sometimes interfere with ovulation. To help you conceive, doctors often recommend adding a medication like cabergoline or bromocriptine to gently lower your prolactin levels. These medications are highly effective and can safely be used alongside your metformin (Glycomet). Your endocrinologist or gynecologist will help tailor the right dosage for you.

Currently, her random blood sugar of 220 mg/dL suggests her diabetes is not fully controlled on her current regimen of Glycomet (metformin) and Tenegliptin. While these are excellent medications, her body may need a dosage adjustment or an additional treatment to bring those numbers down safely. I recommend scheduling a consultation with her doctor. They will likely suggest a fasting and HbA1c blood test to get a clearer picture of her average blood sugar and safely adjust her plan. Please rest assured, with a few medical adjustments, her blood sugar can be well managed.