While you are actively taking Yasmin (a contraceptive pill), your chances of getting pregnant are extremely low, as its main job is to prevent pregnancy. The other medications, Glycomet SR (metformin) and Normoz (myo-inositol), help manage insulin levels and support your metabolism, which actually helps prepare your body for a healthy pregnancy in the future. If you are hoping to conceive, you will just need to safely stop taking Yasmin under your doctor's guidance.

Switching from Glycomet (metformin) to Glycomet plus PPG 0.2 (metformin and voglibose), and now to Amaryl M1 (glimepiride and metformin) indicates your body may need a different approach to manage insulin resistance or insulin production. Over time, diabetes management needs to evolve. Seeing an endocrinologist is an excellent idea. A specialist can tailor a treatment plan specifically for your body's current needs to safely bring your fasting and post-meal sugars into balance.

Your bloating could indeed be related to Glycomet SR (metformin), as digestive changes are common with this medication. While metformin doesn't typically cause sharp pain, your polycystic ovary condition (PCOD) can sometimes contribute to pelvic discomfort. Sharp pain during urination and bowel movements, along with chronic constipation, are classic signs that could point to painful bladder syndrome or pelvic floor issues. I highly recommend speaking with your doctor or a gynecologist. They can safely determine the exact cause of your symptoms and help you find relief.

Since your fasting levels are high and you previously required insulin (Toujeo and Humalog) and metformin (Glycomet SR), your body likely needs a combination of these treatments again. It is very important to see your doctor or an endocrinologist immediately for a proper evaluation and a personalized prescription.

Because your symptoms didn't improve with anti-reflux medicines like pantoprazole/domperidone (Panplus D) or rebamipide (Rebagem), the burning might not be standard reflux. It could be a side effect of other medications you are taking, such as nicorandil or metformin, which can sometimes irritate the digestive tract. Alternatively, diabetes can sometimes cause nerve-related burning, which might require adjusting your pregabalin or amitriptyline. Please share this with your doctor so they can safely review your medication plan.

Since your period is two days late, you can take a home pregnancy test now, preferably using your first morning urine for the most accurate result. Please do not stop taking your Glycomet (metformin) to try and force your period. Metformin helps manage your PCOS by regulating your insulin and hormones, which actually supports ovulation and a healthy pregnancy. Stopping it suddenly can disrupt your cycle further. If the test is negative, wait a few days and test again, and consult your doctor before making any medication changes.