Overview of Nephrotic Syndrome Management

• Focus on reducing proteinuria, controlling symptoms, and preventing complications.

Advanced Medical Therapies

• Consider immunosuppressive agents like corticosteroids, calcineurin inhibitors (e.g., cyclosporine, tacrolimus), mycophenolate mofetil, and rituximab.
• Tailor therapy based on the underlying cause and patient response.

Supportive Treatments

• Use ACE inhibitors or ARBs to reduce proteinuria and protect kidney function.
• Employ diuretics for edema management and statins for lipid control.

Monitoring and Follow-up

• Regularly monitor kidney function, proteinuria levels, blood pressure, and medication side effects.

Advanced Interventions

• Consider plasmapheresis in select cases.
• A kidney biopsy may guide therapy if not recently done.
• Referral to a nephrologist specialized in glomerular diseases is recommended for personalized care.

Lifestyle and Supportive Measures

• Implement dietary modifications such as salt restriction and adequate protein intake.
• Ensure vaccination and infection prevention due to immunosuppression.

When to Consider Renal Replacement Therapy

• Dialysis or kidney transplantation may be necessary if progression to end-stage kidney disease occurs.