Bactrim DS tablet is Sulfa base tablet, if a patiant allready knows with Sulfa tablet skin alergy earlier can take.
If a patient has a known allergy to sulfa drugs, they should avoid taking Bactrim DS (Sulfamethoxazole + Trimethoprim), as it contains a sulfonamide antibiotic that can trigger allergic reactions ranging from mild skin rashes to severe reactions like Stevens-Johnson syndrome; even if previous responses were mild, caution is strongly advised, and a healthcare provider should be consulted to consider safer alternative antibiotics.