I'm sorry to hear about the severe pain you're experiencing from the hole in your lower tooth. It sounds quite uncomfortable, especially since the toothpaste and medications you're using aren't providing relief.

A hole in a tooth causing severe pain often indicates significant tooth decay or possibly an infection that may require professional dental treatment. While the antibiotics you mentioned (Cifran CT, which contains ciprofloxacin and tinidazole) and pain reliever (Zerodol P) can help manage infection and pain, they may not fully resolve the underlying issue if the tooth damage is advanced.

Here are some important steps you should take:

• See a dentist as soon as possible for a thorough examination. They can assess the extent of the decay or infection and recommend appropriate treatment, which may include a filling, root canal therapy, or extraction if necessary.
• Avoid self-medicating further without professional guidance, as inappropriate use of antibiotics can lead to resistance or side effects.
• Maintain good oral hygiene but avoid irritating the painful tooth further.
• If the pain worsens, you develop swelling, fever, or difficulty swallowing, seek emergency dental care immediately.

Please consult a dentist promptly to address this issue effectively and prevent complications. If you experience severe symptoms or an emergency, contact emergency services right away.To narrow down potential causes, we will need some more information.I understand you're in severe pain due to a hole in your tooth and that Sensodyne, Cifran CT, and Zerodol P aren't helping. To assist you better, could you please provide your age and gender?