Premature ejaculation can be influenced by stress, anxiety, and long-term health conditions, and your high blood pressure and BP medicines also need to be considered before choosing any treatment. There is no single “best” medicine for everyone, especially when BP issues are present. The most effective and safe approach usually includes stress management, lifestyle changes, and medical guidance. You should consult a doctor or urologist before taking any medication, as some treatments for premature ejaculation may interact with BP medicines. A doctor can suggest safe options, such as counselling, behavioural techniques, or appropriate medicines if needed, tailored to your condition. Avoid self-medication; proper evaluation is essential for achieving safe, effective results.