Fepace OD Tablet is not commonly known to cause constipation, but individual responses can vary. Since your doctor prescribed it after understanding your condition, you should not replace or stop the tablet on your own. If you notice constipation or worsening of piles or fissures after starting the medicine, inform your doctor, who can decide whether a change is needed and may also advise dietary measures, such as increased fibre and fluids, to help prevent constipation.