When considering the safety of taking Sinarest (which contains chlorpheniramine maleate, paracetamol, and phenylephrine) alongside Folitrax 7.5 (methotrexate), it is important to be cautious.

• Potential interactions: There is no direct, severe interaction reported between these medications, but phenylephrine (a decongestant) can sometimes increase blood pressure or cause other side effects that might complicate your overall health.

• Methotrexate considerations: Methotrexate is an immunosuppressant and can affect liver function. Paracetamol (acetaminophen) is generally safe but should be used cautiously to avoid liver strain.

• Recommendation: It is best to consult your prescribing doctor or a pharmacist before combining these medications. They can assess your specific health status, current methotrexate dose, and any other conditions you may have.

• Monitoring: If your healthcare provider approves this combination, monitor for any unusual symptoms such as increased fatigue, jaundice, or changes in blood pressure.

Always avoid self-medicating when on methotrexate, and keep your healthcare team informed about all medicines you take to ensure safe and effective treatment.