Diabetes-related neuropathy, pinched nerves, or nerve irritation can all cause burning and numbness in the thigh. If you have diabetes, monitor your blood sugar and refrain from applying pressure to the affected area. See a doctor for an assessment if the pain or numbness continues, gets worse, or interferes with movement.

Sciatica-related lower back pain can irritate nerves that pass to the knee, hip, and waist, making walking uncomfortable. When moving, strain might be increased by muscle weakness, stiffness, or bad posture. Persistent pain necessitates a medical evaluation and physical therapy since it indicates continued nerve compression.