Isotroin (isotretinoin) commonly causes dryness throughout the body, including the lining of your digestive tract. When you pass hard stools, this dryness makes the mucosal lining more vulnerable to tiny, painful tears (anal fissures) that can bleed. While this is a known and manageable side effect, it is important to stay hydrated, eat fiber-rich foods, and consult your doctor. They can suggest a gentle stool softener or local ointment to help you heal and feel much more comfortable.
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Can taking one Isotroin 10 mg tablet daily for a month cause bleeding when passing hard stools?