Is it safe to initiate oral isotretinoin (20 mg) combined with topical adapalene/benzoyl peroxide for resistant oily skin after previous topical treatments have failed, and what should be expected regarding side effects and routine blood monitoring?
Generally, we advise against combining oral isotretinoin with topical adapalene/benzoyl peroxide, as both are highly drying and can severely irritate your skin. When starting oral isotretinoin, it is best to stop these strong topicals. You can expect common side effects like dry skin, lips, and eyes. Because isotretinoin requires careful management, routine blood tests to monitor your liver health and cholesterol are standard, along with monthly pregnancy tests, as this medication cannot be taken during pregnancy.