The recurring swelling you are experiencing is likely angioedema. A highly common cause in patients with high blood pressure is a class of medications called ACE inhibitors (such as lisinopril), which can trigger this reaction even after years of uneventful use. Aspirin can also sometimes cause or worsen this swelling. Please consult your physician or cardiologist immediately to review your medication list. They can safely transition you to an alternative blood pressure medication (like an Angiotensin Receptor Blocker or Calcium Channel Blocker) and evaluate your aspirin use. Do not stop taking your heart medications without direct medical supervision, as doing so could be dangerous.

A creatinine level of 4.2 indicates severe kidney strain. There is no single medication to directly lower creatinine; treatment focuses on protecting the kidneys from further damage. Since he had angioplasties, his kidneys may be affected by contrast dye or certain heart medications. It is crucial to consult a nephrologist (kidney specialist) and his cardiologist immediately. They will likely review and adjust his current medications, tightly control his blood pressure, and recommend dietary changes (like reducing salt and protein). Avoid over-the-counter pain relievers (NSAIDs) as they can worsen kidney function. Immediate medical supervision is necessary.

The heart's structural and functional unit is the cardiomyocyte (heart muscle cell). These cells contract in a coordinated way to pump blood throughout the body.