For dark facial pigmentation (likely melasma or sunspots), your wife should consult a dermatologist for a proper diagnosis. Commonly prescribed medicated creams contain active ingredients like Hydroquinone (a skin-lightening agent), Tretinoin (a retinoid to boost cell turnover), or Azelaic Acid. Often, a dermatologist-prescribed 'triple combination cream' works best. Over-the-counter options containing Vitamin C, Kojic Acid, or Niacinamide can also help. Most importantly, she must apply a broad-spectrum sunscreen (SPF 30 or higher) daily, as UV exposure worsens pigmentation and makes treatments ineffective. Avoid using strong steroid creams without medical supervision.

Spots around the hands, legs, and eyes are often due to pigmentation, sun exposure, or conditions like Melasma, so the most important step is daily sunscreen use along with gentle skin care and avoiding harsh products. You can use doctor-advised creams containing agents like kojic acid or azelaic acid to gradually lighten spots.

There is no conclusive evidence that Melalite Forte Cream (Hydroquinone) causes skin cancer in humans. However, prolonged use may cause sun sensitivity, skin thinning, irritation, dryness, and ochronosis (a permanent bluish-black skin discolouration). Use only as prescribed and avoid long-term unsupervised application.

Dark patches on the face in a 45-year-old woman are most commonly due to conditions like melasma, sun-related pigmentation, or post-inflammatory pigmentation, and the treatment depends on the exact cause. The most important step is strict sun protection using a good sunscreen every day, wearing a scarf or hat outdoors, and avoiding direct sun exposure as much as possible, because the sun is the main trigger for worsening pigmentation. Topical treatments prescribed by a dermatologist, such as depigmenting creams (for example, combinations containing hydroquinone, retinoids, or azelaic acid), can gradually lighten the patches when used correctly. Chemical peels or laser treatments may also be options in stubborn cases under specialist care. It is also helpful to check for contributing factors like hormonal changes or thyroid issues if pigmentation is widespread or worsening. Since many treatments need supervision, it is best to consult a dermatologist for proper diagnosis and a safe, tailored treatment plan.

Facial pigmentation or dark patches can occur due to sun exposure, acne marks, hormonal changes, melasma, skin irritation, allergy, or repeated use of unsuitable creams. Since you have already tried many ointments without much improvement, it is important to first identify the exact cause of the pigmentation before continuing treatment. One of the most important steps is regular sun protection, because sunlight can make pigmentation darker and harder to treat. Use a broad-spectrum sunscreen with SPF 30 or higher every day, even while indoors or during cloudy weather, and reapply it if you stay outside for long periods. Wash your face with a gentle face wash twice daily and avoid harsh scrubbing, strong bleaching creams, or steroid-containing creams without medical advice, as these may worsen pigmentation over time. Creams containing ingredients such as vitamin C, niacinamide, azelaic acid, kojic acid, or mild retinoids may help gradually reduce pigmentation, but improvement usually takes several weeks to months and should be done carefully to avoid irritation. Eating a healthy diet, drinking enough water, sleeping well, and managing stress may also support skin health. If the pigmentation is spreading, associated with itching, or not improving despite regular care, you should consult a dermatologist. The doctor can examine your skin closely and decide whether you have melasma, post-acne pigmentation, allergy-related pigmentation, or another skin condition, and may suggest prescription creams, chemical peels, or other treatments if needed. Avoid expecting instant results, because pigmentation treatment usually requires patience and consistent skin care.

You may use creams containing skin-lightening agents such as mild hydroquinone, kojic acid, or niacinamide. Apply only to the affected areas, use sunscreen on exposed skin, and avoid long-term unsupervised use. Please consult your doctor before using these creams to rule out any underlying conditions.