Your body is currently adjusting to two major changes: the recent removal of your copper IUD, which can temporarily sensitize the uterine lining, and starting medroxyprogesterone acetate (Meprate). This hormonal medication works to stabilize your uterine lining, but it often takes a few weeks or even a couple of cycles for your body to fully adapt, during which light breakthrough bleeding or spotting is normal. I recommend keeping a brief log of these symptoms and sharing them with your doctor at your next visit to ensure everything is settling down as expected.

After finishing a course of Meprate (medroxyprogesterone acetate), it typically takes 3 to 10 days for your period to start, but it can sometimes take up to 14 days. Since it has been 9 days, your body might just need a little more time to respond to the hormone changes. I suggest waiting another 5 days. In the meantime, if there is any chance of pregnancy, doing a quick home test is a helpful step. If your bleeding doesn't start after 14 days, please gently follow up with your doctor.

It is quite common for your period to take up to 10 to 14 days to start after finishing Meprate (medroxyprogesterone acetate). Since it has been eight days, your body may just need a little more time. Additionally, your slightly elevated TSH level of 5.98 indicates mild underactive thyroid activity, which can also contribute to irregular cycles and delayed bleeding. I recommend waiting a few more days. If your period does not start within two weeks of stopping the medication, or if you suspect pregnancy, please consult your doctor. They can help evaluate your thyroid and guide your next steps.

It is quite common for your period to take up to 10 to 14 days to start after finishing Meprate (medroxyprogesterone). Your symptoms of breast pain and cramping are actually positive signs that your body is responding to the hormone, and your period may arrive very soon. Since your pregnancy test is negative, you can safely wait another 3 to 4 days. If your period still does not start by then, please consult your gynecologist to discuss the next steps.

Please reassure your wife and have her stop taking Meprate immediately. Meprate contains medroxyprogesterone, a hormone not recommended during pregnancy. However, accidental, short-term exposure in the very early stages of pregnancy rarely causes significant harm or birth defects, and most of these pregnancies progress normally. She should consult her gynecologist as soon as possible. The doctor will likely perform an ultrasound to confirm the pregnancy's health and monitor the baby's development. Please avoid taking any further self-prescribed medications.

Since your pregnancy test is negative, there are a few common reasons for this delay. With PCOS, your body's natural estrogen levels might be quite low, meaning the uterine lining is too thin to shed easily after taking Meprate (medroxyprogesterone acetate). Additionally, hormonal imbalances associated with PCOS and weight can sometimes extend the timeline for a withdrawal bleed up to two to three weeks. The bloating you are feeling is also a common side effect of progesterone. I recommend waiting a few more days and contacting your gynecologist for a quick check-in if it doesn't arrive soon.