Pilex tablets and Ano Metrogyl ointment are commonly used to help soothe swelling and pain from hemorrhoids or anal fissures, and they can be safe for temporary relief. However, three painful, swollen lumps could indicate severe hemorrhoids or an infection, which require proper evaluation. While using these, try taking warm water baths (sitz baths) to ease the discomfort, drink plenty of water, and avoid straining. If you experience severe pain, fever, or bleeding, please try to seek medical attention, perhaps via a telemedicine consultation, as soon as possible.