Bedwetting during sleep can happen for several reasons, such as deep sleep, stress, anxiety, an overactive bladder, constipation, urinary infections, diabetes, drinking too much fluid before bed, or delayed bladder control signals. Some people have this issue since childhood, while for others, it may start later because of emotional stress or a medical problem. Although it can feel embarrassing, bedwetting is more common than many realise. Simple lifestyle changes can sometimes help. Cutting back on tea, coffee, soft drinks, and heavy fluids before bedtime may reduce nighttime urine production. Making sure to empty the bladder before sleep and keeping a regular sleep schedule can also help improve control over time. There are different treatments depending on the cause, but medicines or bladder-control therapy should only be started after getting proper medical advice.

Since the homeopathic treatment was ineffective, I recommend consulting a pediatrician. For deep sleepers with bedwetting (nocturnal enuresis), conventional medical treatments are highly successful. The most common first-line medication is Desmopressin (DDAVP), which temporarily reduces nighttime urine production. For deep sleepers, combining this with a bedwetting alarm is highly recommended, as it trains the brain to recognize a full bladder and wake up. Additionally, limit evening fluids, avoid caffeine, and ensure the patient urinates twice before bed (once before the routine and again right before sleeping). A doctor can provide a safe, tailored prescription.

It is very reassuring that your blood tests and ultrasounds are completely normal. Since you have been taking Minirin (desmopressin) 0.2 mg for 20 days with continued occasional bedwetting, your next best step is to follow up with your prescribing doctor or a urologist. They can evaluate if a dose adjustment is needed or explore other options. In the meantime, try limiting fluid intake for two hours before bedtime, avoiding caffeine and alcohol in the evening, and ensuring you empty your bladder right before sleep.

At 23, experiencing constant fatigue, dry mouth, and extreme thirst (drinking 6 litres of water daily) are classic symptoms of elevated blood sugar, which could indicate Diabetes Mellitus (such as Type 1 Diabetes). Another less common possibility is Diabetes Insipidus. You should not take any medication without a formal diagnosis. It is critical that you see a doctor immediately for blood and urine tests, including fasting blood glucose and HbA1c, to determine the exact cause. Once diagnosed, your physician will prescribe the correct treatment, which may involve insulin or other targeted medications. Please seek medical evaluation promptly.