It is completely normal to experience shifts in your bowel patterns when taking these medications. Your treatment regimen can certainly influence this change. Shelcal M (calcium) can slow down digestion, while Nexito (escitalopram) affects serotonin levels in your gut, altering bowel transit. Aciloc (ranitidine) reduces stomach acid, and Cremaffin Plus is a laxative that directly stimulates bowel movements; the specific time you take Cremaffin Plus will heavily dictate your bowel schedule. These combined effects are likely why your routine has shifted to the evening. There is no cause for concern, but do discuss this with your doctor if you wish to adjust your medication timing to restore a morning routine.