When considering the safety of Ondansetron (Ondem MD 4) and Ranitidine (R Loc D 150) during pregnancy, especially in the second trimester, it's important to understand the general guidance and consult your healthcare provider.

• Ondansetron is commonly used to treat severe nausea and vomiting in pregnancy. It is generally considered safe if prescribed by a doctor, particularly after the first trimester. However, caution is advised during the first trimester due to a small potential risk of oral cleft defects.

• Ranitidine is classified as a Category B medication in pregnancy, meaning no risks have been found in clinical research. It is considered safe if prescribed by a doctor and used only when clearly needed, with benefits outweighing any risks.

• Since you are taking these medications on alternate days, it is important to continue following your doctor's instructions and not change the dosage or frequency without consulting them.

• Always keep your obstetrician informed about all medications you are taking so they can monitor your pregnancy and adjust treatment if necessary.

If you have any concerns or experience new symptoms, please reach out to your obstetrician promptly for personalized guidance.