It is completely understandable to feel frustrated, but please do not worry. The medication you are takinga combination of escitalopram and clonazepamtypically takes two to six weeks to show its full antidepressant effects. Additionally, temporary insomnia can sometimes occur when starting this therapy or as a symptom of depression itself. Please do not stop taking your medication abruptly, as this can cause withdrawal symptoms. Instead, consult your prescribing doctor. They can safely adjust your dosage, change the timing of your dose to help you sleep better, or discuss alternative treatments to ensure you get the relief you need.

I understand your frustration. Since your current regimen (Petril Plus and Mirtaz 7.5) isn?t providing relief, please consult your psychiatrist before making any changes. Do not stop these medications abruptly. Your doctor may consider adjusting the doses or switching to alternative options like SNRIs (e.g., Duloxetine) or Bupropion. For lifestyle support, aim for 30 minutes of daily moderate exercise, maintain a strict sleep schedule, and limit alcohol and caffeine. Combining medical treatment with Cognitive Behavioural Therapy (CBT) is also highly effective for treatment-resistant depression. Please schedule a follow-up to safely optimise your plan.