Your blood sugar readings and HbA1c indicate borderline controlled diabetes, but weight gain while on Amaryl (glimepiride) and Piopar (pioglitazone) is a common side effect, particularly with pioglitazone. The best approach is not to change medications on your own. You should consult your doctor, who may review your current regimen, assess diet and physical activity, and consider adjustments such as changing doses, switching medications, or adding weight-neutral or weight-reducing diabetes medicines. Meanwhile, focusing on a balanced diet, portion control, and regular physical activity can help manage weight and improve blood sugar control.

Diabetes mellitus can affect sexual health in several ways due to long-term high blood sugar damaging nerves and blood vessels. In men, it can lead to erectile dysfunction, reduced libido, and difficulty achieving or maintaining erections. In women, it may cause vaginal dryness, decreased sexual desire, and discomfort during intercourse. Diabetes can also increase the risk of urinary and genital infections, which may further impact sexual well-being. Proper blood sugar control, healthy lifestyle measures, and consulting a healthcare professional can help prevent or manage these sexual health complications.

In type 2 diabetes mellitus, high blood sugar levels cause the body to lose more water through urine in an effort to eliminate excess glucose, a process called osmotic diuresis. This leads to dehydration, which triggers the brain to increase the sensation of thirst, making the person feel unusually thirsty (polydipsia). Persistent excessive thirst is often an early sign of poorly controlled blood sugar. It indicates that the body is trying to maintain fluid balance in the presence of elevated glucose levels.