Using lubricant eye drops like Systane Ultra or Refresh Tears daily is generally very safe, even for years. They do not have serious long-term side effects. However, because both contain mild preservatives, using them more than four times a day over many years can sometimes cause slight irritation. If you need them very frequently, switching to preservative-free individual vials of either brand is a gentler option. Neither brand is universally 'better'?Refresh Tears uses a different lubricant (carboxymethylcellulose) than Systane Ultra, so it comes down to which one feels most comfortable in your eyes.
Ask Apollo
AI powered Health Chatbot
Are there any long-term side effects of using Systane Ultra eye drops daily for years, and is Refresh Tears a better option for dry eyes?