You can take Rifagut 400 (rifaximin) with or without food, so an empty stomach is perfectly fine. For Darolac (a probiotic), it is typically best taken with or just before a meal to help the beneficial bacteria survive. Most importantly, please space them apart: take your Darolac at least 2 hours before or after your Rifagut. This prevents the antibiotic from inactivating the friendly bacteria in the probiotic, ensuring both work effectively for you.
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When is the best time to take Rifagut 400 and Darolac, and can I take both of them on an empty stomach?