Chlorthalidone+efonidipine

Do not use Chlorthalidone+efonidipine if you are allergic to any of its components, penicillin, or sulphonamide antibiotics. Please inform your doctor if you are taking any prescription and non-prescription medications, including vitamins and herbal supplements, before starting Chlorthalidone+efonidipine to rule out any side effects and interactions. Chlorthalidone+efonidipine should be used with caution in elderly patients, starting with the lowest recommended dose, as they are at high risk of reduced kidney, liver, or heart function. Chlorthalidone+efonidipine is not recommended for patients with certain medical conditions, such as severe liver failure, severe kidney failure (creatinine clearance 30 mL/min), anuria (no urine production), low blood pressure (less than 90 mm of Hg), severe electrolyte imbalances (including low levels of potassium, sodium, or magnesium in the blood), Addison's disease (a condition where the adrenal glands do not produce enough steroid hormones), and a history of uric acid kidney stones or gout. Chlorthalidone+efonidipine should not be used by pregnant or breastfeeding women unless advised by a doctor. Chlorthalidone+efonidipine is not recommended for children under 18 years old due to a lack of information for this age group. Chlorthalidone+efonidipine may cause dizziness, so avoid standing up too quickly from a sitting or lying position. Also, avoid driving or operating any machines until you are fully alert after taking Chlorthalidone+efonidipine. Stay hydrated and avoid hot weather, as Chlorthalidone+efonidipine increases the frequency of urination. Additionally, inform your doctor before taking Chlorthalidone+efonidipine if you are on a low salt diet, have recently taken lithium or an anesthetic, or have certain medical conditions, such as diabetes mellitus (high blood sugar), hyperlipidemia (high cholesterol levels), glaucoma (increased eye pressure), hypertensive crisis (severe increase in blood pressure), recent heart attack, or liver or kidney problems.

Drug-drug interactions: Chlorthalidone+efonidipine may interact with certain medications, such as stomach acid reducers (cimetidine), immunosuppressants (tacrolimus), corticosteroids (prednisolone, betamethasone), anticancer drugs (cyclophosphamide, methotrexate), asthma medications (salbutamol, formoterol), antibiotics (amphotericin B), medicine to treat heart failure (digoxin), medicine to treat diabetes (insulin), anticholinergics (atropine, hyoscine), painkillers (aspirin, indomethacin), antipsychotic drugs (lithium), and other blood pressure medications (lisinopril, propranolol, methyldopa, amlodipine).

Drug-food interactions: Avoid consuming alcohol while taking Chlorthalidone+efonidipine, as it may increase the risk of side effects. Also, avoid consuming grapefruit juice and grapefruit, as they may enhance the blood pressure-lowering effect of Chlorthalidone+efonidipine.

Drug-disease interactions: Chlorthalidone+efonidipine is not recommended for patients with certain medical conditions, such as severe liver failure, severe kidney failure (creatinine clearance <30 mL/min), anuria (no urine production), low blood pressure (less than 90 mm of Hg), severe electrolyte imbalances (including low levels of potassium, sodium, or magnesium in the blood), Addison's disease (a condition where the adrenal glands do not produce enough steroid hormones), and have a history of uric acid kidney stones or gout.

• Eat a healthy diet focused on unprocessed foods, such as vegetables, whole grains, fruits, lean proteins, and low-fat dairy. Consider following the DASH diet (Dietary Approaches to Stop Hypertension).
• Limit your sodium (salt) intake to less than 1,500 mg per day, and avoid packaged or processed foods and snacks high in sodium.
• Drink enough fluids or water to avoid dehydration and limit sugary drinks.
• Avoid excessive alcohol consumption and refrain from smoking cigarettes, as this may increase the risk of high blood pressure.
• Engage in moderate-intensity exercise or at least 150 minutes per week.
• Get enough sleep for at least 7-9 hours per night.
• Practice stress-relief techniques such as deep breathing, meditation, or mindfulness to help manage stress-related blood pressure.

• Regularly monitor your blood pressure, electrolytes, liver enzymes, and kidney function tests, and seek medical advice if you notice any significant fluctuations.
• Avoid consuming grapefruit juice and grapefruit while taking Chlorthalidone+efonidipine, as it may increase the blood levels of the active ingredient Efonidipine, potentially leading to an unpredictable increase in the blood pressure-lowering effect of Chlorthalidone+efonidipine