Inclisiran
About Inclisiran
Inclisiran is used to lower low-density lipoprotein cholesterol (LDL-C), commonly known as bad cholesterol, in patients with hyperlipidemia. Hyperlipidemia is a condition marked by elevated levels of lipids (fats), such as cholesterol and triglycerides, in the blood, which can increase the risk of heart disease, stroke, and other health complications.
Inclisiran contains Inclisiran, a PCSK9 inhibitor monoclonal antibody. It works by blocking PCSK9, a protein that regulates receptors on liver cells responsible for clearing LDL-C from the bloodstream. Inhibiting PCSK9 increases the number of LDL receptors, which lowers LDL-C levels and reduces the risk of atherosclerotic cardiovascular diseases.
A healthcare professional will administer Inclisiran. In some cases, this medicine may cause side effects like headache, dizziness, cough, bronchitis, diarrhoea, back pain, pain in a joint, or injection site reactions. The majority of these side effects may not require medical treatment and will subside with time. However, if the side effects persist or worsen, consult a doctor.
Inclisiran should not be administered if you are allergic to it. Before receiving the injection, inform your doctor about any allergies, medications, or conditions that may affect your treatment, such as a history of heart, liver, or kidney disorder. Pregnant and breastfeeding women should consult their doctor before receiving Inclisiran. Inclisiran is not recommended for children below 18 years, as its safety and efficacy have not been established.
Uses of Inclisiran
Treatment of atherosclerotic cardiovascular disease (ASCVD): Inclisiran lowers the levels of low-density lipoprotein (LDL) cholesterol in individuals with clinical ASCVD. This helps reduce the risk of other cardiovascular issues by preventing cholesterol from blocking blood flow in the arteries.
Medicinal Benefits
Inclisiran effectively reduces LDL cholesterol (LDL-C) in adults with heterozygous familial hypercholesterolemia (HeFH) or clinical atherosclerotic cardiovascular disease (ASCVD). Lowering LDL cholesterol helps prevent cholesterol buildup on the arterial walls, thereby reducing the risk of blockages that can restrict blood flow to the heart, brain, and other vital organs. It has minimal interactions with most other cholesterol-lowering medications, making it suitable for use in combination with other treatments.
Directions for Use
Storage
Side Effects of Inclisiran
- Headache
- Dizziness
- Cough
- Diarrhoea
- Bronchitis
- Back pain
- Pain in a joint
- Injection site reactions (pain, swelling, redness)
Drug Warnings
Inform your doctor if you are allergic to any of the components in Inclisiran. If you are pregnant or breastfeeding, consult your doctor before receiving Inclisiran. Let your doctor know if you have a history of heart disease, kidney or liver disease, allergic reactions, breathing problems, arthritis, psoriasis, eczema, urinary tract infections or if you have had any recent vaccinations. Inclisiran is not recommended for children below 18 years, as its safety and efficacy have not been established.
Drug Interactions
Drug-Drug Interactions: No interactions found/established.
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: No interactions found/established.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionIt is unknown if alcohol interacts with Inclisiran. Please consult a doctor if you have any concerns.
Pregnancy
cautionPlease consult a doctor if you are pregnant or planning for pregnancy. Your doctor will prescribe only if the benefits outweigh the risks.
Breast Feeding
cautionThere is limited data on the use of Inclisiran during breastfeeding. Consult your healthcare provider to assess risks and benefits.
Driving
cautionInclisiran is unlikely to impair your ability to drive or operate machinery. However, sometimes, Inclisiran makes you feel tired and dizzy; if it happens to you, do not drive or operate machinery.
Liver
cautionInform your doctor if you have liver impairment. Your doctor will weigh the benefits and any potential risks before prescribing Inclisiran.
Kidney
cautionInform your doctor if you have kidney impairment. Your doctor will weigh the benefits and any potential risks before prescribing Inclisiran.
Children
cautionInclisiran is not recommended for children below 18 years, as its safety and efficacy have not been established.
Habit Forming
Diet & Lifestyle Advise
- To improve heart health, include omega-3-rich foods like salmon, mackerel, and sardines in your diet.
- Limit dietary cholesterol from eggs, shellfish, and fatty meats.
- Limit alcohol to moderate levels to avoid increasing cholesterol.
- Relaxation techniques such as meditation and yoga might help you manage your stress.
- Minimize processed and refined carbohydrates like white bread and sugary snacks.
- Exercise for at least 30 minutes most days to raise HDL and lower LDL cholesterol.
- Maintain a healthy weight to help lower LDL levels.
- Quit smoking to improve HDL cholesterol and overall heart health.
Patients Concern
Disease/Condition Glossary
Hyperlipidaemia: Hyperlipidaemia is a condition characterized by high levels of lipids (fats), such as cholesterol and triglycerides, in the blood. This can lead to an increased risk of cardiovascular diseases, as excess lipids can build up in the walls of arteries, causing blockages and restricting blood flow.
Heterozygous familial hypercholesterolemia (HeFH): Heterozygous familial hypercholesterolemia is a genetic condition where a person inherits one copy of the mutated gene responsible for high cholesterol from one parent. This causes high levels of low-density lipoprotein (LDL) cholesterol in the bloodstream. Individuals with HeFH have a higher risk of developing cardiovascular diseases, such as heart attacks or strokes, due to the buildup of cholesterol in the arteries.
Atherosclerotic cardiovascular disease (ASCVD): Atherosclerotic cardiovascular disease (ASCVD) refers to a group of heart and blood vessel conditions caused by the accumulation of fatty deposits, or plaques, in the arteries. This process, known as atherosclerosis, can lead to reduced blood flow, increasing the risk of heart attack, stroke, and other cardiovascular problems.
FAQs
Inclisiran is used to reduce low-density lipoprotein cholesterol (LDL-C) in adults with heterozygous familial hypercholesterolemia (HeFH) or clinical atherosclerotic cardiovascular disease (ASCVD) who need further reduction of LDL-C.
Inclisiran contains Inclisiran, a PCSK9 inhibitor monoclonal antibody. It works by lowering the amount of LDL cholesterol in the blood, decreasing the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.
Inclisiran is usually given as an initial dose, followed by a second dose after 3 months, and then administered every 6 months thereafter.
If a dose is missed by less than 3 months, the doctor will administer Inclisiran and continue the original dosing schedule. If more than 3 months are missed, a new schedule will be started with an initial dose, another dose at 3 months, and then every 6 months.
No dose adjustment is required for elderly patients, but caution is advised when administering Inclisiran to individuals with severe renal disease, as they may be at a higher risk for complications. Close monitoring is important during treatment.
Some people may experience reactions at the injection site, such as pain, redness, or swelling, but these typically resolve on their own. Seek medical advice if the reactions persist.
PCSK9 is a protein that regulates the number of LDL receptors on cells. These receptors help control cholesterol levels by binding to LDL particles, which carry cholesterol in the blood. Most of these receptors are in the liver, where they remove excess cholesterol from the body.
Pregnant or breastfeeding women should consult their healthcare provider before using Inclisiran, as its safety during pregnancy and breastfeeding is not fully established.
The side effects of Inclisiran may include headache, dizziness, cough, bronchitis, diarrhoea, back pain, or pain in a joint. Seek medical care if the side effects persist or worsen.
Inclisiran may increase the risk of urinary tract infections. Consult the doctor if you experience symptoms of urinary tract infection like frequent urination, pain/burning sensation during urination, pelvic/rectal pain, discoloured urine or smelly urine.
Available Medicines for
Inclisiran
Sybrava PFS 284 mg Injection 1.5 ml 1's
1 Prefilled Syringe
₹98477.1 (MRP 120094)18%Off
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