Do not take OFLOXACIN if you are allergic or have had a severe reaction to ofloxacin or any other quinolone or fluoroquinolone antibiotics such as delafloxacin, gemifloxacin, levofloxacin, moxifloxacin, and ciprofloxacin. Taking OFLOXACIN may increase the chances of developing tendinitis (swelling of a fibrous tissue that connects a bone to a muscle) or have a tendon rupture (tearing of a fibrous tissue that connects a bone to a muscle). Inform your doctor if you have or have ever had a kidney, heart, or lung transplant, kidney disease, a joint or tendon disorder such as rheumatoid arthritis (an autoimmune disorder of joints causing pain, swelling, and loss of function), seizures (fits), epilepsy or if you participate in regular physical activity. Taking OFLOXACIN may worsen muscle weakness in people with myasthenia gravis (a nervous system disorder that causes muscle weakness) and cause severe difficulty breathing or death. Dairy products should be avoided along with OFLOXACIN. And also, exposure to sunlight should be avoided while taking OFLOXACIN as it may cause increased phototoxicity or photosensitivity. Patients with epilepsy and irregular heartbeat (QT prolongation) should tell their doctor before taking OFLOXACIN.

Drug-drug interaction: This medicine may have an interaction with blood thinners (aspirin, warfarin), antidepressants and antipsychotics (clozapine, olanzapine), caffeine-containing medications, insulin, or other anti-diabetic medications (chlorpropamide, glimepiride, glipizide, glyburide, metformin, tolazamide, and tolbutamide), medications for regulating irregular heartbeat (amiodarone, disopyramide, procainamide, quinidine), pain killers (ibuprofen, naproxen). Take OFLOXACIN either 2 hours before or 2 hours after taking an antacid, multivitamin, or other product that has calcium/magnesium/aluminum/iron/zinc, antiulcer agent (sucralfate), or anti-HIV drug (didanosine).

Drug-Food Interaction:  OFLOXACIN interacts with dairy products (milk or yogurt) or calcium-fortified juices alone.

Drug-Disease Interaction: Inform your doctor if you have or have ever had tendon rupture, musculoskeletal problem (myopathy, rhabdomyolysis), kidney/heart/lung transplant,  low blood potassium (hypokalemia), kidney disease, rheumatoid arthritis, seizures (fits), epilepsy or any other neurological disorder if you participate in regular physical activity before starting OFLOXACIN.

• Do not drink or eat a lot of caffeine-containing products such as coffee, tea, energy drinks, cola, or chocolate. OFLOXACIN may increase nervousness, sleeplessness, and anxiety caused by caffeine.
• Probiotics should be taken after taking the full course of OFLOXACIN to restore some healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhea. Certain fermented foods like yogurt, cheese, sauerkraut, kombucha, and kimchi can help restore the intestine's good bacteria. 
• Include more fiber-enriched food in your diet, as it can be easily digested by your gut bacteria, which helps stimulate their growth. Thus, fiber-rich foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains like whole-grain bread, brown rice should be included in your diet. Make sure you drink plenty of water or other fluids every day while you are taking OFLOXACIN.
• Avoid alcoholic beverages with OFLOXACIN as it can make you dehydrated and may affect your sleep. This can make it harder for your body to aid the OFLOXACIN in fighting off infections.

Tendon damage (especially to the Achilles tendon) can occur within 48 hours of starting OFLOXACIN treatment. The onset of symptoms and signs of the side effects may be delayed several months after stopping treatment. At the first sign of tendinitis (like painful swelling, inflammation), immediately stop taking OFLOXACIN. The affected limbs should be appropriately treated (e.g., immobilisation). Corticosteroids medicines (like anti-inflammatory drugs including cortisone, prednisone, prednisolone, methylprednisolone, dexamethasone, betamethasone, hydrocortisone should not be used if signs of tendon rupture occur.