About TIZANIDINE+DICLOFENAC
TIZANIDINE+DICLOFENAC is a combination medicine that contains pain relievers and muscle relaxants. It is used to treat spasticity (muscle stiffness and spasms) associated with pain. Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. A muscle spasm occurs due to involuntary contractions of a muscle. A spasm may be a muscle cramp or feel tight or stiff, like a knot.
TIZANIDINE+DICLOFENAC contains Diclofenac (NSAID) and Tizanidine (muscle relaxant). Diclofenac blocks prostaglandins (PGs) that cause pain and swelling. Tizanidine works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements. As a result, TIZANIDINE+DICLOFENAC helps to reduce muscle stiffness, spasms, and pain.
TIZANIDINE+DICLOFENAC is prescribed medication, and it should be taken as directed by the doctor. In some cases, you may experience common side effects such as feeling or being sick (vomiting), diarrhoea, headaches, drowsiness and ringing in your ears (tinnitus), fluctuations in blood pressure, dry mouth, stomach upsets, and decrease or increase in heart rate. Most of these side effects do not require medical attention and will resolve gradually. However, you are advised to talk to your doctor if you experience these side effects persistently.
Before prescribing TIZANIDINE+DICLOFENAC, inform your doctor about all your allergic or hypersensitivity reactions to medicines or food. Also, tell your doctor about your medical history and other medications you are currently taking to rule out any potential adverse effects. Do not take TIZANIDINE+DICLOFENAC unless recommended by the doctor if you are pregnant or planning pregnancy or breastfeeding. TIZANIDINE+DICLOFENAC may cause dizziness, so drive only if you are alert and focused. TIZANIDINE+DICLOFENAC should not be given to children as safety has not been established. Avoid consuming alcohol while on treatment with TIZANIDINE+DICLOFENAC as it could lead to liver damage.
Uses of TIZANIDINE+DICLOFENAC
Spasticity (muscle stiffness and spasms) is associated with pain.
Medicinal Benefits
TIZANIDINE+DICLOFENAC contains Diclofenac (NSAID) and Tizanidine (muscle relaxant). Diclofenac inhibits the production of prostaglandins (PGs), which induce pain and swelling. Tizanidine modulates the spinal cord and brain centres. This aids in the relief of muscle stiffness and the improvement of muscle movements. As a result, TIZANIDINE+DICLOFENAC aids in relieving muscle stiffness, spasms, and pain.
Directions for Use
Storage
Side Effects of TIZANIDINE+DICLOFENAC
Vomiting
Diarrhoea
Headaches
Drowsiness
Ringing in your ears (tinnitus)
Fluctuations in blood pressure
Dry mouth
Stomach upsets
Decrease or increase in heart rate
In-Depth Precautions and Warning
Drug Warnings
Do not take TIZANIDINE+DICLOFENAC if you are allergic to its components. Inform your doctor about all your medical conditions, especially if you have/ had hepatotoxicity, hypotension, renal dysfunction or renal toxicities, asthma, fluid retention, GI toxicity, rash, or thrombosis (blood clots). It is not recommended to take TIZANIDINE+DICLOFENAC during pregnancy or whilst breastfeeding. TIZANIDINE+DICLOFENAC may cause drowsiness and dizziness, so drive only if you are alert. TIZANIDINE+DICLOFENAC is not recommended for children as safety and effectiveness have not been established. Do not stop taking TIZANIDINE+DICLOFENAC unless your doctor tells you to. Treatment with TIZANIDINE+DICLOFENAC should be stopped gradually. Stopping treatment suddenly may cause effects such as an increase in heart rate and high blood pressure.
Drug Interactions
Drug-Drug Interactions: TIZANIDINE+DICLOFENAC may interact with certain pain killers (e.g. hydrocodone), anti-depressants (e.g. fluvoxamine, escitalopram), antibiotics (e.g. ciprofloxacin), antihypertensives (e.g. metoprolol), anticoagulant (e.g. apixaban), certain painkillers (e.g. celecoxib), and antiretroviral medicine (e.g. tenofovir).
Drug-Food Interactions: Do not drink alcohol while taking TIZANIDINE+DICLOFENAC.
Drug-Disease Interactions: TIZANIDINE+DICLOFENAC may interact with various disease conditions that include ulcer or perforation, bleeding problems, hepatotoxicity (liver impairment), hypotension, renal dysfunction or toxicities, asthma, fluid retention, GI toxicity, rash, thrombosis (blood clots).
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid consumption of alcohol while taking TIZANIDINE+DICLOFENAC as it may cause increased drowsiness. It may also increase the risk of stomach bleeding.
Pregnancy
cautionTIZANIDINE+DICLOFENAC is not recommended for use in pregnant women. If you are pregnant or planning pregnancy, inform your doctor before taking TIZANIDINE+DICLOFENAC.
Breast Feeding
cautionTIZANIDINE+DICLOFENAC is not recommended for use in breastfeeding mothers. If you are breastfeeding, consult your doctor before taking TIZANIDINE+DICLOFENAC.
Driving
cautionTIZANIDINE+DICLOFENAC may cause dizziness or drowsiness. So, do not drive or operate machinery unless you are alert.
Liver
cautionInform your doctor before receiving TIZANIDINE+DICLOFENAC if you have a liver impairment/disorder history. TIZANIDINE+DICLOFENAC is not recommended for use in severely impaired liver function patients.
Kidney
cautionInform your doctor before receiving TIZANIDINE+DICLOFENAC if you have a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.
Children
unsafeTIZANIDINE+DICLOFENAC is not recommended for children as safety and effectiveness are not established.
Habit Forming
Diet & Lifestyle Advise
Regular exercise helps muscle stretch, making them less likely to spasm, tear, and sprain. Mild activities such as jogging and walking are helpful for muscle stretching.
Massages can also be helpful.
Rest well, and get plenty of sleep.
Change your position at least every two hours to avoid developing pressure sores.
Hot or cold therapy can help treat muscle spasms. Apply an ice pack or hot pack on the muscle for 15-20minutes.
Stay hydrated, drink plenty of water.
Patients Concern
Disease/Condition Glossary
Muscle spasm is the sudden involuntary contractions of the muscle, which can be painful and uncomfortable. When the nerve impulses that control the muscle movements are damaged or interrupted, it could lead to muscle spasms. A spasm may be a twitch in the muscle or feel tight or hard, like a knot.
Pain: Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Pain may be dull or sharp; it might be constant or may come and go. The tolerance level of pain might vary from person to person. Pain can be generalized (overall body aches) or localized (affecting a specific body area). The common causes of pain include headache, muscle strain, cramps, cuts, bone fractures, and arthritis.
