Stomach pain has many causes, so the right medicine depends on the source. For acid burning, an antacid or famotidine helps. For gas, try simethicone. For mild cramping, acetaminophen is generally safe, but you must avoid NSAIDs like ibuprofen or aspirin, as they can irritate your stomach lining and worsen the pain. Because stomach pain can sometimes indicate a serious condition (like appendicitis or ulcers), do not self-medicate if the pain is severe, constant, or accompanied by fever, vomiting, or dark stools. Please consult a doctor for a proper diagnosis.