Nighttime leg cramps are common, but it is best to start with simple lifestyle adjustments rather than prescription drugs. First, stay well-hydrated and perform gentle calf stretches before bed. You may consider trying an over-the-counter magnesium supplement, but consult your doctor first, especially if you have kidney issues. Avoid taking quinine, as it is no longer recommended due to safety risks. Since cramps can also be a side effect of other medications (like statins or diuretics) or point to underlying circulation issues, please see your physician for a personalized evaluation before starting any new medication.