Yes, it is quite possible that these new itchy bumps on your leg are connected to your recent hives. Sometimes, allergic reactions can recur if the underlying trigger is still present in your environment, or it could be a delayed phase of the initial reaction. While Allegra (fexofenadine) helps manage symptoms, it does not prevent new flares if exposure continues. It could also be a localized reaction, like contact dermatitis. Please try to keep the area clean and avoid scratching. If the bumps spread, become painful, or if you develop any swelling or breathing issues, please seek medical evaluation.

Based on your description, this could be a common condition called dyshidrotic eczema, which causes tiny, intensely itchy blisters on the hands. Since oral fexofenadine (Allegra) and calamine lotion haven't provided relief, it is best to consult a healthcare professional. They can confirm the diagnosis and may prescribe a targeted treatment, such as a topical corticosteroid cream, which is often much more effective for this condition. In the meantime, try to use gentle, fragrance-free cleansers, keep your hands moisturized, and avoid scratching.

While Allegra (fexofenadine) is generally safe, it is unlikely to have caused her to pass out on its own. However, fexofenadine is an antihistamine for allergies and will not effectively treat her cold, stuffy nose, or headache. Because of her complex health history, weak immune system, and the fainting episode, please have her evaluated by a doctor right away before giving her any new medications.

Since there is no improvement with the current treatments, the lesion could be a fungal infection (like tinea capitis), which can actually worsen with topical corticosteroids. Other possibilities include a resistant bacterial infection (like impetigo) or severe eczema with a secondary infection. I gently recommend stopping the steroid cream and taking her to see a pediatrician or pediatric dermatologist. They can perform a simple scalp scraping or swab to identify the exact cause and prescribe the correct, targeted medication to help her skin heal safely.

Allegra (fexofenadine) is a daily medication that typically wears off within 24 hours. Once the medicine leaves your system, the itching returns because the underlying cause of your reaction is still active. Since the itching is severe and keeps coming back, I highly recommend scheduling an appointment with your doctor or an allergist. They can help identify the root cause, safely adjust your daily dose of fexofenadine, or recommend other targeted treatments to give you lasting relief.

The improvement after taking Allegra (fexofenadine) suggests an allergic reaction, such as hives. However, the weakness and tingling in your hands and feet are systemic symptoms that require careful attention. These can sometimes occur with viral infections, severe allergic reactions, or certain medication side effects. Because you are experiencing weakness and tingling, it is very important that you get evaluated by a healthcare professional promptly to ensure your safety and find the exact cause. Please rest, stay hydrated, and seek medical care today.