It sounds like you might have Type 2 diabetes or insulin resistance, a condition in which the body does not react well to insulin, leading to tiredness and poor control even with medication. When this occurs, treatment frequently requires modification; in addition to medication, a consistent regimen of a healthy diet (low sugar, regulated carbohydrates), frequent exercise, weight control, and restful sleep is crucial. Please see your doctor for blood tests (such as sugar levels and HbA1c) if you feel your body is "not cooperating" or if medications are bothering you so they may safely adjust the dosage or medications.