1. Temporary Numbness: Applying Lox 2% Jelly on the penis can cause temporary numbness or reduced sensation, which typically wears off after a few hours.

2. Permanent Numbness: Permanent numbness is very unlikely with proper use. Overuse or misuse might lead to irritation or other side effects.

3. Precautions:a. Avoid applying large amounts or using it too frequently.b. If you experience persistent numbness, pain, or unusual symptoms, stop using it and consult a healthcare professional.

4. Consultation: Discuss with a doctor if you have underlying conditions or concerns before using topical anesthetics.

In summary, Lox 2% Jelly should not cause permanent numbness when used as directed. Always use cautiously and follow medical advice.