Within a few days to a week, Medrol (methylprednisolone) typically begins to reduce pain and inflammation. A rheumatologist may need to modify the dosage or long-term RA treatment if significant discomfort continues.

Seronegative inflammatory arthritis, early rheumatoid arthritis, or other autoimmune disorders are frequently indicated by joint and wrist swelling with elevated CRP but negative RF.?This can also be caused by infections, gout, or connective tissue disorders, which require additional medical testing.